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” He and Munakata feel that gradual modifications in the way the DNA is stored may lead to some loss of fertility as Ladies age. If so, their analysis could pave just how for improved treatment method and diagnosis of fertility troubles.
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Using the GCRLE grant, Munakata and Namekawa will seem extra closely at how oocytes are genomically primed and saved for afterwards use. They are going to investigate the role of a chromatin remodeler in oocyte survival and fertility.
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Namekawa believes that in human oocytes, variations in these patterns could disrupt the fragile choreography of genes currently being turned on and off at the proper moments — leaving them unprepared for fertilization or development into healthier embryos. Variations in chromatin structure being an oocyte ages may additionally impact the way in which that chromosomes segregate through mobile division.
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